June 1992
Volume 33, Issue 7
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Articles  |   June 1992
A rabbit corneal epithelial cell line expresses functional platelet-derived growth factor beta-type receptors.
Author Affiliations
  • M Knorr
    Department of General Ophthalmology, University of Tübingen, Germany.
  • K P Steuhl
    Department of General Ophthalmology, University of Tübingen, Germany.
  • D Tatje
    Department of General Ophthalmology, University of Tübingen, Germany.
  • J Hoppe
    Department of General Ophthalmology, University of Tübingen, Germany.
Investigative Ophthalmology & Visual Science June 1992, Vol.33, 2207-2211. doi:
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    • Get Citation

      M Knorr, K P Steuhl, D Tatje, J Hoppe; A rabbit corneal epithelial cell line expresses functional platelet-derived growth factor beta-type receptors.. Invest. Ophthalmol. Vis. Sci. 1992;33(7):2207-2211.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Platelet-derived growth factor (PDGF) is a family of three isoforms termed PDGF-AA, PDGF-AB, or PDGF-BB that induce proliferation in various mesenchymal cells. A rabbit corneal epithelial cell line (SIRC) was chosen to study the effects of the three isoforms of PDGF. These cells express approximately 43,000 PDGF beta-type receptors and less than 2800 alpha-type receptors on their surface. Thus, only PDGF-BB and -AB led to a transient dose-dependent rise in cytosolic free calcium with an effective dose for 50% of cells of 5 ng/ml. The PDGF-induced calcium signal is largely independent of the presence of extracellular calcium.

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