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A Tyutyunikov, R B Raikow, J S Kennerdell, M Kazim, M H Dalbow, D Scalise; Re-examination of peripheral blood T cell subsets in dysthyroid orbitopathy.. Invest. Ophthalmol. Vis. Sci. 1992;33(7):2299-2303.
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Patients with dysthyroid orbitopathy (DO) were grouped according to a multifactorial assessment of disease severity and the rate of disease progression. Using this system and flow cytometric measurements of T cell subsets in the peripheral blood, a significant increase in the percentage of CD4+ lymphocytes correlated with disease severity in DO patients with progressive disease. These observations are consistent with the hypothesis that the CD4+ peripheral blood T helper cells play a significant role in the progression of DO.
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