June 1992
Volume 33, Issue 7
Free
Articles  |   June 1992
Re-examination of peripheral blood T cell subsets in dysthyroid orbitopathy.
Author Affiliations
  • A Tyutyunikov
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
  • R B Raikow
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
  • J S Kennerdell
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
  • M Kazim
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
  • M H Dalbow
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
  • D Scalise
    Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
Investigative Ophthalmology & Visual Science June 1992, Vol.33, 2299-2303. doi:
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      A Tyutyunikov, R B Raikow, J S Kennerdell, M Kazim, M H Dalbow, D Scalise; Re-examination of peripheral blood T cell subsets in dysthyroid orbitopathy.. Invest. Ophthalmol. Vis. Sci. 1992;33(7):2299-2303.

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Abstract

Patients with dysthyroid orbitopathy (DO) were grouped according to a multifactorial assessment of disease severity and the rate of disease progression. Using this system and flow cytometric measurements of T cell subsets in the peripheral blood, a significant increase in the percentage of CD4+ lymphocytes correlated with disease severity in DO patients with progressive disease. These observations are consistent with the hypothesis that the CD4+ peripheral blood T helper cells play a significant role in the progression of DO.

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