July 1992
Volume 33, Issue 8
Free
Articles  |   July 1992
The antineoplastic effect of vitamin D in transgenic mice with retinoblastoma.
Author Affiliations
  • D M Albert
    David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston.
  • D M Marcus
    David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston.
  • J P Gallo
    David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston.
  • J M O'Brien
    David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston.
Investigative Ophthalmology & Visual Science July 1992, Vol.33, 2354-2364. doi:
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    • Get Citation

      D M Albert, D M Marcus, J P Gallo, J M O'Brien; The antineoplastic effect of vitamin D in transgenic mice with retinoblastoma.. Invest. Ophthalmol. Vis. Sci. 1992;33(8):2354-2364.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Vitamin D has been shown to inhibit growth of human retinoblastoma in tissue culture and nude mouse heterografts. We have described a heritable transgenic mouse model of retinoblastoma. The in vivo efficacy of 1,25-dihydroxycholecalciferol (vitamin D3) was examined by administering this agent to transgenic mice with retinoblastoma. Forty-six 8-10-week-old transgene-bearing mice were injected intraperitoneally for 5 wk. Experimental animals received 0.05 microgram (15 animals) or 0.025 microgram (15 animals) of vitamin D. Sixteen control animals received only a mineral oil vehicle. Eyes were enucleated at 5 mo and were examined histologically by two investigators in a masked fashion. All control animals demonstrated bilateral involvement of retinoblastoma. Four eyes in the low-dose group and six eyes in the high-dose group had no evidence of retinoblastoma. Eyes treated with vitamin D3 showed less extensive involvement of the retina by retinoblastoma. Vitamin D-treated animals demonstrated tumors confined to the retina, whereas control animals demonstrated larger tumors, more often invading the vitreous, anterior chamber, and choroid. Thus, Vitamin D inhibited the growth and local extension in a dose-dependent fashion.

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