June 1992
Volume 33, Issue 7
Free
Articles  |   June 1992
The effect of combined daunorubicin and triamcinolone acetonide treatment on a refined experimental model of proliferative vitreoretinopathy.
Author Affiliations
  • E P Chen
    Department of Ophthalmology, Duke University, Durham, North Carolina.
  • U H Steinhorst
    Department of Ophthalmology, Duke University, Durham, North Carolina.
  • G P Samsa
    Department of Ophthalmology, Duke University, Durham, North Carolina.
  • P T Saloupis
    Department of Ophthalmology, Duke University, Durham, North Carolina.
  • D L Hatchell
    Department of Ophthalmology, Duke University, Durham, North Carolina.
Investigative Ophthalmology & Visual Science June 1992, Vol.33, 2160-2164. doi:
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      E P Chen, U H Steinhorst, G P Samsa, P T Saloupis, D L Hatchell; The effect of combined daunorubicin and triamcinolone acetonide treatment on a refined experimental model of proliferative vitreoretinopathy.. Invest. Ophthalmol. Vis. Sci. 1992;33(7):2160-2164.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Prior studies have shown that intravitreal daunorubicin (9-15 nmol) and triamcinolone acetonide (2 mg) are effective individually in preventing retinal detachment in experimental proliferative vitreoretinopathy. This report compares the efficacy of the combination of daunorubicin (15 nmol) and triamcinolone acetonide (2 mg) with that of daunorubicin alone in a refined experimental model of proliferative vitreoretinopathy. The degree of retinal detachment in each treatment group was graded, with the unequivocal absence or presence of retinal detachment used as an indicator of treatment success or failure. Both treatments (daunorubicin alone and in combination with triamcinolone acetonide) effectively prevented retinal detachment. However, there was no significant difference in the rate of retinal detachment between the two treatment groups. These results indicate that combination therapy with daunorubicin/triamcinolone is no more effective at preventing retinal detachment than daunorubicin alone.

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