January 1993
Volume 34, Issue 1
Free
Articles  |   January 1993
Accelerated heavy particles and the lens. VII: The cataractogenic potential of 450 MeV/amu iron ions.
Author Affiliations
  • B V Worgul
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.
  • D J Brenner
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.
  • C Medvedovsky
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.
  • G R Merriam, Jr
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.
  • Y Huang
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.
Investigative Ophthalmology & Visual Science January 1993, Vol.34, 184-193. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      B V Worgul, D J Brenner, C Medvedovsky, G R Merriam, Y Huang; Accelerated heavy particles and the lens. VII: The cataractogenic potential of 450 MeV/amu iron ions.. Invest. Ophthalmol. Vis. Sci. 1993;34(1):184-193.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

PURPOSE: To determine the cataractogenic potential dose of high velocity iron ions as a fixation of dose administered singly or fractionated. The dose is critical to risk assessment and to theories of radiation action and cataractogenesis. METHODS: Twenty-eight-day-old rats were examined by slit-lamp biomicroscopy on a weekly-bi-weekly basis for more than 2 yr after radiation exposure. For the acute exposure study doses of 1, 2, 5, 25, and 50 cGy were evaluated. The fractionated regimens involved total doses of 2, 25, and 50 cGy. The reference radiation consisted of 50, 100, 200, or 700 cGy of 250 kilovolt (peak) x-rays. RESULTS: In accordance with previous findings in the rat using 570 MeV/amu 40Ar ions, the relative biologic effectiveness increased rapidly with decreasing dose, reaching values as high as 100. Unlike 40Ar ions, fractionation of the 56Fe doses did not produce a consistent enhancement at any of the doses examined. CONCLUSIONS: The data support the previous findings of a high cataractogenic potential for high linear energy transfer (LET) radiation. The effectiveness for the production of cataracts increases with decreasing dose relative to x-rays and is independent of dose protraction. Although the present study did not reveal a consistent enhancement of effect when the ions were applied in fractions, the results are consistent with at least one theory of the inverse dose-rate effect observed for high-LET radiation.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×