January 1993
Volume 34, Issue 1
Free
Articles  |   January 1993
Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye.
Author Affiliations
  • N S Peachey
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • D J Green
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
  • H Ripps
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Investigative Ophthalmology & Visual Science January 1993, Vol.34, 58-65. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      N S Peachey, D J Green, H Ripps; Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye.. Invest. Ophthalmol. Vis. Sci. 1993;34(1):58-65.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

PURPOSE: This study sought to examine the acute effects of ocular ischemia and reperfusion on retinal function and determine the extent to which recovery during reperfusion is improved by allopurinol (AP), a blocker of xanthine oxidase (XO). The latter is presumed to be a major factor in the formation of free radicals associated with reperfusion of ischemic tissue. METHODS: Electroretinographic (ERG) responses were recorded simultaneously from the two isolated, arterially perfused eyes obtained from the same cat. One eye served as the control and received only the standard perfusate; the other eye was infused with AP before and after a 3 hr period of total ischemia. RESULTS: After the prolonged period of nonperfusion, recovery of the electroretinographic components was incomplete to varying degrees. Maximum b-wave amplitudes recovered only to 17 +/- 5% (mean +/- SEM) of baseline, whereas the a-wave grew to 60 +/- 10% of its baseline value. For both measures, the recovery of electroretinographic amplitude was significantly greater in AP-treated eyes than in the control eyes. CONCLUSION: Generation of free radicals by XO contributes to the retinal damage and loss of function that occurs after a period of ischemia and subsequent reperfusion.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×