April 1993
Volume 34, Issue 5
Free
Articles  |   April 1993
Simulation of corneal neovascularization by inverted diffusion limited aggregation.
Author Affiliations
  • G Landini
    Oral Pathology Unit, Dental School, University of Birmingham, England.
  • G Misson
    Oral Pathology Unit, Dental School, University of Birmingham, England.
Investigative Ophthalmology & Visual Science April 1993, Vol.34, 1872-1875. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      G Landini, G Misson; Simulation of corneal neovascularization by inverted diffusion limited aggregation.. Invest. Ophthalmol. Vis. Sci. 1993;34(5):1872-1875.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

PURPOSE: The authors modeled the normally avascular mammalian cornea response to injury by neovascularization. The nature of this process remains obscure, although diffusion mechanisms are thought to be involved. METHODS: Corneal neovascularization was simulated using fractal stochastic computer models for nonequilibrium diffusion (inverted diffusion limited aggregation) and a stochastic ballistic aggregation. RESULTS: The inverted diffusion limited aggregation model was found to generate patterns strikingly similar to those observed in pathologic neovascularization of the cornea in vivo. CONCLUSIONS: This result supports the role of random diffusion mechanisms modified by environmental factors, such as the release of angiogenic factors in corneal angiogenesis.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×