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W B Rathbun, A J Schmidt, A M Holleschau; Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract.. Invest. Ophthalmol. Vis. Sci. 1993;34(6):2049-2054.
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PURPOSE: To assess the activities of the two enzymes required for glutathione synthesis, gamma-glutamylcysteine synthetase and glutathione synthetase, in various forms of human cataracts. METHODS: The Cooperative Cataract Research Group cataract classification method and standard enzyme assay procedures were used. RESULTS: An inverse relationship was shown between residual activity of each of the glutathione synthesis enzymes and degree of subcapsular cataract. A weaker inverse relationship existed between glutathione synthetase activity and supranuclear and nuclear cataracts. No other parameters yielded comparable correlations with the activity of either enzyme. CONCLUSIONS: Activity loss of the glutathione synthesis enzymes is associated with human subcapsular cataract formation.
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