May 1993
Volume 34, Issue 6
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Articles  |   May 1993
Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract.
Author Affiliations
  • W B Rathbun
    Ophthalmology Department, University of Minnesota, Minneapolis 55455.
  • A J Schmidt
    Ophthalmology Department, University of Minnesota, Minneapolis 55455.
  • A M Holleschau
    Ophthalmology Department, University of Minnesota, Minneapolis 55455.
Investigative Ophthalmology & Visual Science May 1993, Vol.34, 2049-2054. doi:
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      W B Rathbun, A J Schmidt, A M Holleschau; Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract.. Invest. Ophthalmol. Vis. Sci. 1993;34(6):2049-2054.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To assess the activities of the two enzymes required for glutathione synthesis, gamma-glutamylcysteine synthetase and glutathione synthetase, in various forms of human cataracts. METHODS: The Cooperative Cataract Research Group cataract classification method and standard enzyme assay procedures were used. RESULTS: An inverse relationship was shown between residual activity of each of the glutathione synthesis enzymes and degree of subcapsular cataract. A weaker inverse relationship existed between glutathione synthetase activity and supranuclear and nuclear cataracts. No other parameters yielded comparable correlations with the activity of either enzyme. CONCLUSIONS: Activity loss of the glutathione synthesis enzymes is associated with human subcapsular cataract formation.

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