September 1996
Volume 37, Issue 10
Free
Articles  |   September 1996
A new method for rapid mapping of the retinal thickness at the posterior pole.
Author Affiliations
  • R Zeimer
    Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Ophthalmic Physics Laboratory, Baltimore, MD 21287-9131, USA.
  • M Shahidi
    Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Ophthalmic Physics Laboratory, Baltimore, MD 21287-9131, USA.
  • M Mori
    Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Ophthalmic Physics Laboratory, Baltimore, MD 21287-9131, USA.
  • S Zou
    Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Ophthalmic Physics Laboratory, Baltimore, MD 21287-9131, USA.
  • S Asrani
    Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Ophthalmic Physics Laboratory, Baltimore, MD 21287-9131, USA.
Investigative Ophthalmology & Visual Science September 1996, Vol.37, 1994-2001. doi:
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    • Get Citation

      R Zeimer, M Shahidi, M Mori, S Zou, S Asrani; A new method for rapid mapping of the retinal thickness at the posterior pole.. Invest. Ophthalmol. Vis. Sci. 1996;37(10):1994-2001.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: An objective, quantitative, and sensitive method to map retinal thickness is needed to diagnose more effectively the conditions causing alterations in thickness, such as macular edema and neuroretinal atrophy. METHODS: An instrument, the retinal thickness analyzer, was developed into a rapid scanning instrument, capable of covering macular areas of 2 x 2 mm in 200 or 400 msec and generating a detailed map of the retinal thickness. The performance was assessed in vitro and in five normal subjects who were scanned on three separate visits. RESULTS: Optimal depth precision was 5 to 10 microns, and the optimal depth resolution was 50 microns. Reproducibility was +/- 12 microns on the same day, +/- 13 microns for single maps obtained in multiple visits, and +/- 10 microns for three averaged maps per visit obtained in multiple visits. CONCLUSIONS: This new method to analyze retinal thickness provides four unique features: multiple optical cross-sectioning of the retina, mapping of retinal thickness, high reproducibility, and short acquisition time. These capabilities promise to improve the diagnosis and management of common diseases such as macular edema and glaucoma.

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