October 1996
Volume 37, Issue 11
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Articles  |   October 1996
Changes in retinal dopaminergic cells and dopamine rhythmic metabolism during the development of a glaucoma-like disorder in quails.
Author Affiliations
  • O Dkhissi
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
  • E Chanut
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
  • C Versaux-Botteri
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
  • F Minvielle
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
  • J H Trouvin
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
  • J Nguyen-Legros
    Laboratoire d'Anatomie Comparée, Muséum National d'Histoire Naturelle, Paris, France.
Investigative Ophthalmology & Visual Science October 1996, Vol.37, 2335-2344. doi:
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      O Dkhissi, E Chanut, C Versaux-Botteri, F Minvielle, J H Trouvin, J Nguyen-Legros; Changes in retinal dopaminergic cells and dopamine rhythmic metabolism during the development of a glaucoma-like disorder in quails.. Invest. Ophthalmol. Vis. Sci. 1996;37(11):2335-2344.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To examine the possible correlation between a dysfunction of the daily rhythm of retinal dopamine (DA) and the development of a glaucoma-like disorder in an animal model, the al mutant quail (Coturnix coturnix japonica). METHODS: The morphology and density of DA-containing cells labeled immunohistochemically with an anti-tyrosine hydroxylase (TH) antibody were correlated with the diurnal and nocturnal contents of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) determined by high-pressure liquid chromatography with electrochemical detection. RESULTS: The number of TH-immunoreactive cells was lower than normal in mutant quails suffering from the disorder. There were considerably fewer cells in the central retina, and the DA metabolism was reduced in parallel. The nocturnal DA content was lower than the diurnal level in normal quails, but there was no such circadian fluctuation in mutant quails. CONCLUSIONS: This glaucoma-like disorder in quails is correlated with the degeneration of DA-containing amacrine cells and a dysfunction of the circadian rhythmicity of DA synthesis.

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