October 1996
Volume 37, Issue 11
Free
Articles  |   October 1996
Injection of autologous blood for bleb leaks in New Zealand white rabbits.
Author Affiliations
  • J W Doyle
    Department of Ophthalmology, University of Florida, Gainesville 32610-0284, USA.
  • M F Smith
    Department of Ophthalmology, University of Florida, Gainesville 32610-0284, USA.
  • J A Garcia
    Department of Ophthalmology, University of Florida, Gainesville 32610-0284, USA.
  • M B Sherwood
    Department of Ophthalmology, University of Florida, Gainesville 32610-0284, USA.
  • T Lau
    Department of Ophthalmology, University of Florida, Gainesville 32610-0284, USA.
Investigative Ophthalmology & Visual Science October 1996, Vol.37, 2356-2361. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J W Doyle, M F Smith, J A Garcia, M B Sherwood, T Lau; Injection of autologous blood for bleb leaks in New Zealand white rabbits.. Invest. Ophthalmol. Vis. Sci. 1996;37(11):2356-2361.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

PURPOSE: Bleb leaks after trabeculectomy with antimetabolites can be recalcitrant to therapy. Peribleb autologous blood injections are a moderately successful new treatment modality for such leaks. However, it is unclear what mechanism the injections work to achieve leak resolution. METHODS: A randomized, prospective study in the rabbit model was undertaken to evaluate further the clinical and histologic effects of peribleb autologous blood injection after leak induction in mitomycin-C exposed blebs, compared to controls that received only peribleb balanced salt solution injections. RESULTS: In the blood-treated eyes, all bleb leaks healed. Control eyes either demonstrated persistent bleb leaks with shallow anterior chambers or failed blebs that were Seidel negative. Histologic results were remarkable for increased peribleb cellularity and collagen deposition in the blood-treated eyes, compared to controls. CONCLUSIONS: Peribleb autologous blood injections are associated with bleb leak resolution, increased peribleb cellularity, and collagen deposition in the rabbit model.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×