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Michael Hove Noergaard, Daniella Bach-Holm, Erik Scherfig, Kurt Bang, Peter Koch Jensen, Jens Folke Kiilgaard, Einar Stefánsson, Morten la Cour; Dorzolamide Increases Retinal Oxygen Tension after Branch Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2008;49(3):1136-1141. doi: 10.1167/iovs.07-0508.
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purpose. To study the effect of dorzolamide on the preretinal oxygen tension (RPO2) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs.
methods. Experimental BRVO was induced by diathermy close to the optic disc. RPO2 was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO2 was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO2 was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide.
results. The average baseline RPO2 was 2.64 ± 0.09 kPa (mean ± SD). In the BRVO-affected areas, RPO2 decreased significantly (by 0.67 ± 0.29 and 0.94 ± 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO2 increased significantly (by 0.51 ± 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO2 was 0.67 ± 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO2 significantly (by 0.36 ± 0.21 kPa at 3 to 4 hours and by 0.67 ± 0.40 kPa) 1 week after BRVO induction.
conclusions. Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.
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