Significant findings of the stereometric parameters of ONH topography obtained for both the entire (0°–360°) and the inferotemporal (270°–360°) regions from 27 ∅HT and 32 +HT subjects (
Table 1, subpopulation C) are presented in
Table 5. For the entire ONH region, the rim volume was significantly greater in the +HT group (
P = 0.032) than in the ∅HT group, when adjusted for age, perfusion pressure, and age at menarche. Age at menarche was a significant predictor of rim volume (
P = 0.014). In the inferotemporal ONH region, the rim volume (
P = 0.042), height variation contour (
P = 0.011), mean RNFL thickness (
P = 0.033), and cross-sectional area (
P = 0.020) were significantly greater in the +HT group than in the ∅HT group. Somewhat similar findings were observed in a subset of women excluding the ones who had hysterectomy only. In both the entire ONH and the inferotemporal region, height variation contour (
P = 0.049,
P = 0.003), mean RNFL thickness (
P = 0.046,
P = 0.006), and RNFL cross-sectional area (
P = 0.045,
P = 0.011) were significantly greater in 23 +HT than in 26 ∅HT postmenopausal women when adjusted for age, perfusion pressure, age at menarche, and menopause duration. Ocular perfusion pressure was a significant predictor for height variation contour (
P = 0.046) and so was age at menarche for the mean RNFL thickness (
P = 0.032) of the entire ONH, whereas ocular perfusion pressure (
P = 0.049) was a predictor for mean RNFL thickness of the inferotemporal region. For both the entire ONH and the inferotemporal region, all other parameters did not reach statistical significance (data not presented).