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Bénédicte Merle, Marie-Noëlle Delyfer, Jean-François Korobelnik, Marie-Bénédicte Rougier, Joseph Colin, Florence Malet, Catherine Féart, Mélanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, Cécile Delcourt; Dietary Omega-3 Fatty Acids and the Risk for Age-Related Maculopathy: The Alienor Study. Invest. Ophthalmol. Vis. Sci. 2011;52(8):6004-6011. doi: https://doi.org/10.1167/iovs.11-7254.
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Previous studies have suggested a lower risk for age-related maculopathy (ARM) in subjects with high dietary intake of long-chain omega-3 polyunsaturated fatty acids (PUFA). The authors report the associations of ARM with past dietary intakes in French elderly subjects.
The Alienor Study is a population-based epidemiologic study on nutrition and age-related eye diseases performed in residents of Bordeaux 73 years of age and older. Six hundred sixty-six subjects (1289 eyes) with complete data were included in the analyses. ARM was classified from retinal photographs taken in 2006 to 2008 in five exclusive stages: late neovascular ARM (n = 21 subjects, 29 eyes); late atrophic ARM (n = 19 subjects, 33 eyes); large soft indistinct drusen and/or reticular drusen and/or large distinct drusen with pigment abnormalities (early ARM2, n = 67 subjects, 100 eyes); large soft distinct drusen alone or pigment abnormalities alone (early ARM1, n = 119 subjects, 163 eyes); and no ARM (n = 440 subjects, 964 eyes). Dietary intakes were estimated from a 24-hour dietary recall performed by dieticians (2001–2002). Associations were estimated using logistic Generalized Estimating Equation.
After multivariate adjustment, subjects with high intake of long-chain omega-3 PUFA showed a decreased risk for early ARM1 (odds ratio [OR], 0.83; 95% confidence interval [95% CI], 0.71–0.98; P = 0.03) and late neovascular ARM (OR, 0.26; 95% CI, 0.08–0.83; P = 0.02). Associations with late atrophic ARM were in the same direction but did not reach statistical significance (OR, 0.74; 95% CI, 0.52–1.06; P = 0.10). Overall, high intakes of long-chain omega-3 PUFA were associated with reduced risk for late ARM (OR, 0.59; 95% CI, 0.39–0.88; P = 0.01).
These results confirm a decreased risk for ARM in subjects with high intake of long-chain omega-3 PUFA.
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