1 | Advanced Cell Technology, Marlborough, MA | ESC-RPE | Allogeneic | Spontaneous differentiation | Cell suspension | Phase I/IIa ongoing | AMD-GA |
2 | Pete Coffey, UCL, London, UK, and Pfizer, Tadworth, Surrey, UK | ESC-RPE | Allogeneic | Spontaneous differentiation | Polyester scaffold | Trial begins early 2014 | AMD-wet with rapid vision decline |
3 | PI - Mark Humayun, USC, Los Angeles, CA, Co-PIs - Dennis Clegg, USCB, Santa Barbara, CA, and David Hinton, USC, CIRM, San Francisco, CA | ESC-RPE | Allogeneic | Spontaneous differentiation | Paralene scaffold | IND filing 2014/15 | AMD-GA |
4 | Eyal Banin, HMC, Jerusalem, Israel | ESC-RPE | Allogeneic | Developmentally guided | Cell suspension | GMP optimization, planning pre-clinical work | AMD-GA, Best disease, LCA |
5 | Masayo Takahashi, RIKEN, Wako-shi, Saitama, Japan, and Helios, Tokyo, Japan | iPSC-RPE | Autologous | Developmentally guided | RPE sheet, no scaffold | IRB approved, trial begins 2014/15 | AMD-CNV |
6 | Pete Coffey, UCL and Pfizer | iPSC-RPE | Autologous | u.d. | Polyester scaffold | Planning | AMD-RPE tear |
7 | Kapil Bharti & Sheldon Miller, NEI, NIH, Bethesda, MD | iPSC-RPE | Autologous & allogeneic | Developmentally guided | Biodegradable scaffold | Planning cGMP optimization | AMD-GA, Stargardt's, RP |
8 | David Gamm, UW, Madison, WI | iPSC-retina/RPE | Autologous | Developmentally guided | Complex tissue | Planning proof-of-principle | AMD-GA |
9 | Sally Temple, NSCI, Rensselaer, NY | Adult RPE | Allogeneic | No differentiation | Cell suspension/Scaffold | Planning cGMP optimization | AMD-GA |
10 | Janssen R&D, Beerse, Belgium | Umbilical tissue derived stem cells | Allogeneic | No differentiation | Cell suspension | Phase I/IIa ongoing | AMD-GA |
11 | Stem Cell, Inc., Newark, CA | Fetal neural stem cells | Allogeneic | No differentiation | Cell suspension | Phase I/IIa ongoing | AMD-GA |
12 | Henry Klassen, UCI, CIRM | Fetal retinal progenitors | Allogeneic | No differentiation | Cell suspension | GMP optimization, planning pre-clinical work | RP |