November 1989
Volume 30, Issue 11
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Articles  |   November 1989
Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow.
Author Affiliations
  • M S Korenfeld
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
  • B Becker
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Investigative Ophthalmology & Visual Science November 1989, Vol.30, 2385-2392. doi:
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      M S Korenfeld, B Becker; Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow.. Invest. Ophthalmol. Vis. Sci. 1989;30(11):2385-2392.

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Abstract

We report a significant decrease in intraocular pressure after intravitreal injection of atrial natriuretic peptide (AP). There is also an increase in cGMP in iris-ciliary body preparations after exposure to physiologic concentrations of AP in vitro. We present evidence that after intravitreal AP administration there is a decrease in aqueous humor flow associated with the decrease in intraocular pressure. The changes in aqueous humor flow were estimated by automated fluorophotometry and aqueous humor ascorbate concentrations.

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