February 1990
Volume 31, Issue 2
Free
Articles  |   February 1990
Rate of flow of aqueous humor determined from measurements of aqueous flare.
Author Affiliations
  • J W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.
  • S D Trocme
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.
  • S Relf
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.
  • R F Brubaker
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.
Investigative Ophthalmology & Visual Science February 1990, Vol.31, 339-346. doi:
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    • Get Citation

      J W McLaren, S D Trocme, S Relf, R F Brubaker; Rate of flow of aqueous humor determined from measurements of aqueous flare.. Invest. Ophthalmol. Vis. Sci. 1990;31(2):339-346.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Measurement of light scattered in the anterior chamber can provide important clinical information about the eye. In this study, a scanning ocular spectrofluorophotometer was used to measure scattering in the anterior chamber. Pathologic scattering (flare) was induced by argon laser photocoagulation of the iris in pigmented rabbits. The spectrally corrected intensity of the flare in inflamed eyes decreased as the inverse 2.2 power of the wavelength of the illuminating beam. The strongest signal with this instrument was measured at 470 nm. Diurnal variation of normal and spontaneous scatter from the aqueous humor was measured in nine pigmented rabbits entrained to a 12-hr light/12-hr dark cycle and in eight human subjects. A technique is described for determining the rate of flow of aqueous humor from scattered light when the transfer rate of scattering substance into the anterior chamber is constant. This technique was used to study changes in flow over the diurnal cycle. The rate of flow in human subjects during sleep was 60% of the rate during waking hours. In rabbits, the rate was lowest (44% of maximum) during the 6 hr after the lights were turned on, and were greatest just before the lights were turned on. These findings confirm previous studies of the circadian rhythm of aqueous humor flow in rabbits and humans.

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