February 1990
Volume 31, Issue 2
Articles  |   February 1990
Restoring sensitivity to timolol after long-term drift in primary open-angle glaucoma.
Author Affiliations
  • S A Gandolfi
    Istituto di Oftalmologia, Università di Parma, Italy.
Investigative Ophthalmology & Visual Science February 1990, Vol.31, 354-358. doi:
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      S A Gandolfi; Restoring sensitivity to timolol after long-term drift in primary open-angle glaucoma.. Invest. Ophthalmol. Vis. Sci. 1990;31(2):354-358.

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      © ARVO (1962-2015); The Authors (2016-present)

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In a prospective randomized single-masked study lasting 6 months, 39 eyes with primary open-angle glaucoma showing a long-term drift with 0.5% timolol were put on a "timolol holiday" lasting 30 or 60 days. Twenty-three of them were enrolled with dipivefrin 0.1% twice daily during the holiday. When timolol therapy was restored, the dipivefrin-treated group showed a more pronounced decrease of intraocular pressure (IOP) (8.2 +/- 1.5), whereas the IOP decrease in the nondipivefrin-treated group was lower (3.9 +/- 1.2) and of shorter duration (less than 60 days). Among the dipivefrin-treated group, the response to timolol was more prolonged in the eyes treated for 60 days: the IOP of these eyes was less than 23 mmHg throughout the follow-up.


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