March 1990
Volume 31, Issue 3
Free
Articles  |   March 1990
Corneal epithelial barrier function after oxybuprocaine provocation in diabetics.
Author Affiliations
  • T R Stolwijk
    Department of Ophthalmology, Leiden University Hospital, The Netherlands.
  • J A van Best
    Department of Ophthalmology, Leiden University Hospital, The Netherlands.
  • J P Boor
    Department of Ophthalmology, Leiden University Hospital, The Netherlands.
  • H H Lemkes
    Department of Ophthalmology, Leiden University Hospital, The Netherlands.
  • J A Oosterhuis
    Department of Ophthalmology, Leiden University Hospital, The Netherlands.
Investigative Ophthalmology & Visual Science March 1990, Vol.31, 436-439. doi:https://doi.org/
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      T R Stolwijk, J A van Best, J P Boor, H H Lemkes, J A Oosterhuis; Corneal epithelial barrier function after oxybuprocaine provocation in diabetics.. Invest. Ophthalmol. Vis. Sci. 1990;31(3):436-439. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Corneal epithelial permeability for fluorescein was determined after provocation by a local anesthetic in 18 non-insulin-dependent diabetes mellitus (NIDDM) patients, 23 insulin-dependent diabetes mellitus (IDDM) patients, and 22 healthy controls to evaluate the corneal epithelial barrier function in diabetes. All volunteers had Oxybuprocaine instilled into one eye and saline into the other eye. The epithelial permeability values were determined by fluorophotometry, and the ratio between both eyes was calculated for each individual. The mean permeability values of the saline-instilled eyes in the diabetic patients did not differ significantly from those in the healthy controls (P greater than 0.2). The individual ratios between Oxybuprocaine- and saline-instilled eyes in the NIDDM and IDDM patients differed significantly from those in the healthy controls (mean ratios: 2.6, 1.9, and 1.0, respectively; P less than 0.002). The permeability ratios and the percentage glycosylated hemoglobin (HbAlc) were linearly correlated in the NIDDM patients but not in the IDDM patients (r = 0.73, P less than 0.001, and r = 0.09, P greater than 0.68, respectively). The results showed that the corneal epithelial barrier function in the diabetic patients was not impaired compared with that in the healthy controls. After provocation by a local anesthetic, the barrier function was impaired in the diabetic patients only.

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