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Sakae Ikeda, Norman L. Hawes, Bo Chang, Cindy S. Avery, Richard S. Smith, Patsy M. Nishina; Severe Ocular Abnormalities in C57BL/6 but Not in 129/Sv p53-Deficient Mice. Invest. Ophthalmol. Vis. Sci. 1999;40(8):1874-1878.
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purpose. To demonstrate the importance of genetic background interaction on the
development of ocular phenotypes in p53-deficient mice.
methods. Eyes of adult mice, homozygous and heterozygous for the p53 gene
disruption in the 129/SvJ and C57BL/6J (B6) genetic backgrounds, and
their F1 progeny were examined by indirect ophthalmoscopy and by light
results. Indirect ophthalmoscopy revealed unilateral or bilateral vitreal
opacities, fibrous retrolental tissue, and retinal folds in adult B6
mice but not in 129/Sv mice homozygous for a p53 null mutation. In B6
p53−/− mice, blood vessels extended from the peripapillary inner
retina through the posterior vitreous and into the retrolental
membrane. Optic nerves were hypoplastic.
conclusions. These findings indicate that alleles from the B6 background contribute
to the aberrant ocular phenotypes observed in p53 deficiency. They also
suggest that p53 or the pathway in which it functions may be important
for normal eye development.
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