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Vincenzo Parisi, Gianluca Manni, Stefano A. Gandolfi, Marco Centofanti, Gaspare Colacino, Massimo G. Bucci; Visual Function Correlates with Nerve Fiber Layer Thickness in Eyes Affected by Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 1999;40(8):1828-1833.
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purpose. To test whether the high variability observed when measuring pattern
electroretinogram (PERG), visual evoked potentials (VEP), and spatial
contrast sensitivity (SCS) in eyes with ocular hypertension is
associated with variation in nerve fiber layer thickness, as measured
by optical coherence tomography (OCT).
methods. The study involved 32 untreated eyes (32 patients; age range, 29–64
years) showing a normal white-on-white 24/2 Humphrey (San Leandro, CA)
perimetry, IOP between 23 and 28 mm Hg, best corrected acuity of 20/20
or better, and none of the following papillary signs on conventional
color stereo slides: rim notch(es), peripapillary splinter hemorrhages,
or increased vertical-to-horizontal cup-to-disc ratio. On recruitment,
each eye underwent SCS testing, OCT, PERG, and VEP recordings. Linear
regression (Pearson’s test) or Spearman’s rank regression was adopted
for the analysis of the data.
results. The 95% confidence limits of the electrophysiological data were: PERG
P50 latency, 59.3 to 63 msec; PERG P50 to N95 amplitude, 0.74 to 1.15μ
mV; VEP P100 latency, 113 to 118 msec; VEP N75 to P100 amplitude,
3.81 to 4.90 μmV. The 360° nerve fiber layer thickness overall
(NFLO) ranged between 113 and 169 μm (145 ± 16 μm; mean ± SD) and significantly correlated with PERG P50 to N95 amplitude
(r: 0.518; P = 0.002), PERG P50
latency (r: −0.470; P = 0.007), VEP
N75 to P100 amplitude (r: 0.460; P =
0.008), VEP P100 latency (r = −0.422; P = 0.016) and SCS at 3 cyc/deg (r:−
0.358; P = 0.044).
conclusions. The variability of PERG, VEP, and SCS testing observed in eyes with
ocular hypertension is associated with differences in NFL thickness
(the thinner the layer, the worse the visual
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