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Yasuhiro Konno, Jiro Numaga, Naoyuki Tsuchiya, Atsuko Ogawa, S. M. Monowarul Islam, Manabu Mochizuki, Hiroshi Mitsui, Hiromi Oda, Hiroo Maeda; HLA-B27 Subtypes and HLA Class II Alleles in Japanese Patients with Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 1999;40(8):1838-1844.
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purpose. Some patients with anterior uveitis (AU) have ankylosing spondylitis (AS)
and are HLA-B27 class I–positive. The purpose of this study was to
investigate whether there are differences in HLA at the allele level
among each group of patients with AU.
methods. Seventy-three patients with AU were studied. They were classified into
three groups: 31 with AS-associated AU, 14 with HLA-B27–associated AU,
and 28 with idiopathic AU. Three control groups without AU were used:
138 random subjects, 33 HLA-B27–positive healthy subjects, and 19
HLA-B27–positive patients with AS. DRB1 and DQB1 genotyping was
performed using polymerase chain reaction (PCR)–single-strand
conformation polymorphism (PCR-SSCP) and PCR–restriction fragment
length polymorphism. HLA-B27 subtype was determined by PCR-SSCP.
results. There was no difference in the frequency of any class I antigen except
HLA-B27 among the patients studied. The frequencies of HLA-DR12 in
AS-associated AU and HLA-DR1 in HLA-B27–associated AU showed an
increase. In HLA-B27–associated AU, DRB1*0101 and DQB1*0501 were
increased compared with HLA-B27–positive control subjects. When
HLA-B27 subtype distribution was compared among the groups, the
proportion of B*2704 was significantly lower in HLA-B27–associated AU
(P = 0.037), however, such a difference was not present in
conclusions. These results indicated that B*2704 seemed to be less susceptible to AU
compared with B*2705 in Japanese subjects. The increase of HLA-DR12 and
HLA-DR1 in AU may be caused by linkage disequilibrium with B*2704 and
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