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Vincenzo Parisi, Gianluca Manni, Maria Spadaro, Gaspare Colacino, Rita Restuccia, Stefano Marchi, Massimo G. Bucci, Francesco Pierelli; Correlation between Morphological and Functional Retinal Impairment in Multiple Sclerosis Patients. Invest. Ophthalmol. Vis. Sci. 1999;40(11):2520-2527.
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purpose. To assess whether a correlation exists between optic nerve fiber layer
(NFL) thickness and the retinal or visual pathway function in multiple
sclerosis (MS) patients previously affected by optic neuritis.
methods. Fourteen patients with a diagnosis of definite MS were examined. All
had been affected by optic neuritis (MSON) with complete recovery of
visual acuity (14 eyes included in study). These were compared with 14
eyes from 14 age-matched control subjects. NFL thickness was measured
by optical coherence tomography (OCT). Three different measurements in
each quadrant (superior, inferior, nasal, and temporal) were taken and
averaged. The data in all quadrants (12 values averaged) were
identified as NFL Overall, whereas the data obtained in the temporal
quadrant only (3 values averaged) were identified as NFL Temporal.
Retinal and visual pathway function was assessed by simultaneously
recording pattern electroretinograms (PERGs) and visual evoked
potentials (VEPs) using high-contrast (80%) checkerboard stimuli
subtending 15 minutes and 60 minutes of the visual arc (min
arc) and reversed at the rate of two reversals per second.
results. In MSON eyes there was a significant (P < 0.01)
reduction in NFL thickness in both NFL Overall and NFL Temporal
evaluations compared with the values observed in control eyes. PERG,
(15-min arc checks) and VEP (15-min arc and 60-min arc checks), showed
a significant (P < 0.01) delay in latency and
reduction in amplitude. NFL Overall and NFL Temporal values were
significantly correlated (P < 0.01) to the PERG
P50 latency and P50 to N95 amplitude recorded with 15-min arc checks.
No correlations (P > 0.01) between NFL values and
the other electrophysiological data (PERG recorded with 60-min arc
checks and VEP recorded with 15-min arc and 60-min arc checks) were
conclusions. There is a correlation between PERG changes and NFL thickness in MS
patients previously affected by optic neuritis, but there is no
correlation between VEP changes and NFL
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