Purchase this article with an account.
Ko-Hua Chen, Chih-Chiau Wu, Sayon Roy, Shui-Mei Lee, Jorn-Hon Liu; Increased Interleukin-6 in Aqueous Humor of Neovascular Glaucoma. Invest. Ophthalmol. Vis. Sci. 1999;40(11):2627-2632.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
purpose. To demonstrate the involvement of proinflammatory cytokines in
intraocular neovascularization by detecting the presence of interleukin
(IL)-6, IL-2, and tumor necrosis factor (TNF)-α in aqueous humor and
serum of patients with neovascular glaucoma (NVG) secondary to central
retinal vein occlusion (CRVO).
methods. According to the grade of iris neovascularization (NVI), patients with
CRVO were divided into three groups: CRVO without NVI, CRVO with NVI,
and CRVO with regressed NVI. Healthy patients with cataract were
enrolled as control subjects. Enzyme-linked immunosorbent assay was
used to quantitate the concentrations of the cytokines IL-6, IL-2, and
TNF-α in aqueous humor and serum from patients with NVG and control
results. In serum, the levels of IL-6, IL-2, and TNF-α did not differ among
groups. In aqueous humor, only IL-6 showed significant change among
groups. IL-6 levels in aqueous humor of group 2, CRVO with NVI
(1532.0 ± 221.1 pg/ml; P < 0.001), and group 3,
CRVO with regressed NVI (234 ± 154.6 pg/ml; P <
0.001), were significantly higher. There was no significant difference
in IL-6 levels between the control group (26.4 ± 21.8 pg/ml) and
group 1 (15.6 ± 0.9 pg/ml).
conclusions. The inflammatory cytokine IL-6 in aqueous humor increased spatially and
temporally correlated with the grade of NVI in patients of NVG
secondary to CRVO. The aqueous IL-6 increased in NVI and decreased
after vessels regressed. It is possible that the significantly higher
level of IL-6 was due to intraocular synthesis because of the minimal
change in serum. The increased level of IL-6 may have a putative role
along with other angiogenic factors in angiogenesis of NVG as a
possible predictor of NVI.
This PDF is available to Subscribers Only