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Chang-Hua Piao, Mineo Kondo, Atsuhiro Tanikawa, Hiroko Terasaki, Yozo Miyake; Multifocal Electroretinogram in Occult Macular Dystrophy. Invest. Ophthalmol. Vis. Sci. 2000;41(2):513-517.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. Occult macular dystrophy (OMD) is an unusual macular dystrophy
presenting with an essentially normal fundus and fluorescein
angiography but with progressive central visual loss. The authors
studied the function of local retinal areas in the posterior pole of
patients with OMD using multifocal electroretinograms (ERGs).
methods. Multifocal ERGs were recorded using the Visual Evoked Response Imaging
System with 61 hexagonal elements within a visual field of 30° radius
from 8 OMD patients and 20 age-matched, normal subjects. The amplitudes
and implicit times of the patients and normal control subjects were
compared at the various retinal eccentricities.
results. The amplitudes of the multifocal ERGs in the OMD patients were markedly
reduced in the central 7° of the fovea. The difference of the ERG
amplitudes between OMD and normal subjects became smaller toward the
peripheral retina. Most OMD patients had slight but significantly
delayed implicit times across the whole testing field, and the
differences between the OMD and the normal subjects did not change with
conclusions. Our results for multifocal ERG amplitudes support the idea that OMD
patients have localized retinal dysfunction distal to the ganglion
cells in the central retina. The delayed implicit times across the
whole test field suggest that the retinal dysfunction has a broader
boundary than expected by ERG amplitudes and psychophysical perimetric
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