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Megumi Honjo, Hidenobu Tanihara, Sachihiro Suzuki, Taro Tanaka, Yoshihito Honda, Masatoshi Takeichi; Differential Expression of Cadherin Adhesion Receptors in Neural Retina of the Postnatal Mouse. Invest. Ophthalmol. Vis. Sci. 2000;41(2):546-551.
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purpose. To determine the expression pattern of multiple subtypes of cadherin
adhesion receptor in postnatal mouse neural retina.
methods. The expression of N-cadherin, R-cadherin, cadherin-6, cadherin-8, and
cadherin-11 in retinas at postnatal days 0 to 42 was analyzed by in
situ hybridization of mRNA as well as by immunohistochemistry.
results. Each cadherin was expressed by different cell populations of the
retina, and the following expression patterns were established by
postnatal day 14: in the ganglion cell layer, all these molecules were
expressed, but each occurred only in a subset of the cells. Likewise,
in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were
expressed by a restricted population of amacrine cells, and cadherin-8
also by a subpopulation of bipolar cells. All horizontal cells
expressed R-cadherin, and Müller cells expressed N-cadherin and
cadherin-11. Proteins of R-cadherin and cadherin-6 were concentrated in
conclusions. The pattern of differential expression of the five cadherins supports
the idea that these molecules may play a role in selective cell
interactions within the heterogeneous cell pool of the neural
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