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Tuuli U. Linna, Minna H. Vesaluoma, Juan J. Pérez–Santonja, W. Matthew Petroll, Jorge L. Alió, Timo M. T. Tervo; Effect of Myopic LASIK on Corneal Sensitivity and Morphology of Subbasal Nerves. Invest. Ophthalmol. Vis. Sci. 2000;41(2):393-397.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. To investigate whether the morphology of the subbasal nerves
corresponds to corneal sensitivity after laser in situ keratomileusis
methods. In a case series study, 59 patients were examined at 2 to 4 hours, 3
days, 1 to 2 weeks, 1 to 2 months, 3 months, or 6 or more months after
undergoing LASIK for myopia, by using a Cochet–Bonnet esthesiometer
and an in vivo confocal microscope, and were compared with control
subjects. Corneal sensitivity and confocal images of subbasal nerves
were obtained centrally and 2 mm nasally and temporally. Subbasal nerve
fiber bundles (NFBs) were grouped as follows: corneas with no nerve
images; corneas with short (<200 μm), unconnected NFBs; corneas with
long (>200 μm) NFBs without interconnections; and corneas with long
NFBs with interconnections.
results. Corneal sensitivity was at its lowest at 1 to 2 weeks after LASIK.
Sensitivity of the hinge area was higher than temporal or central areas
at every time point. At 6 or more months the sensitivity values were
comparable with the values observed in control subjects. The central
area showed mainly short, unconnected subbasal NFBs, even at 6 months.
In general, the temporal area presented with long NFBs from 3 months
onward, whereas the nasal area showed long NFBs at every time point.
conclusions. The results suggest that the corneal areas with no nerve images or
short, unconnected NFBs are associated with lower sensitivities than
corneal areas with long NFBs with or without interconnections. In vivo
confocal microscopy reveals LASIK-induced alterations of subbasal nerve
morphology and thus enables a direct comparison of corneal sensory
innervation and sensitivity.
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