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Aruki Sonoda, Yasushi Sonoda, Ryuji Muramatu, J. Wayne Streilein, Masahiko Usui; ACAID Induced by Allogeneic Corneal Tissue Promotes Subsequent Survival of Orthotopic Corneal Grafts. Invest. Ophthalmol. Vis. Sci. 2000;41(3):790-798.
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purpose. To determine whether immune deviation is induced by allogeneic corneal
tissue implanted in the anterior chamber and whether survival of
subsequent orthotopic corneal allografts is thereby enhanced.
methods. Corneal tissue from C57BL/6 mice was implanted in the anterior chamber
of eyes of BALB/c mice. The fate of these implants was assessed
histologically, and the donor-specific immune response of recipient
mice was tested for donor-specific delayed hypersensitivity and the
capacity to accept or reject C57BL/6 corneas grafted orthotopically
into the fellow eye.
results. C57BL/6 cornea implants in the anterior chamber failed to induce
donor-specific delayed hypersensitivity but impaired donor-specific
delayed hypersensitivity in a proportion of recipients with implants in
place for 2 weeks. Mice with donor-specific delayed hypersensitivity
rejected the intraocular implants. Mice bearing C57BL/6 cornea implants
in the anterior chamber for 2 (but not 4) weeks accepted the C57BL/6
corneas grafted orthotopically into the fellow eye at a high rate and
with few rejection reactions.
conclusions. Implantation of allogeneic corneal tissue in the anterior chamber of
the eye has the transient capacity to alter the recipient alloimmune
response in a manner that promotes survival of subsequent orthotopic
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