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Tien Yin Wong, Barbara E. K. Klein, Ronald Klein, Sandra C. Tomany, Kristine E. Lee; Refractive Errors and Incident Cataracts: The Beaver Dam Eye Study. Invest. Ophthalmol. Vis. Sci. 2001;42(7):1449-1454.
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purpose. To describe the relation between refractive errors and incident
age-related cataracts in a predominantly white US population.
methods. All persons aged 43 to 84 years of age in Beaver Dam, Wisconsin, were
invited for a baseline examination from 1988 through 1990 and a
follow-up examination 5 years later from 1993 through 1995. At both
examinations, participants had refraction and photographic assessment
of cataract, according to a standardized protocol. Myopia was defined
as a spherical equivalent of −1.0 diopters (D) or less, hyperopia as+
1.0 D or more. The relations between refractive errors at baseline and
cataract at baseline (prevalent cataract), 5-year incident
cataract, and incident cataract surgery were analyzed by using
generalized estimating equations.
results. When age and gender were controlled for, myopia was related to
prevalent nuclear cataract (odds ratio [OR], 1.67; 95% confidence
interval [CI], 1.23–2.27), but not to cortical and posterior
subcapsular cataracts. Myopia was not related to 5-year incident
nuclear, cortical, and posterior subcapsular cataracts, but was related
to incident cataract surgery (OR 1.89; CI 1.18–3.04). Hyperopia was
related to incident nuclear (OR 1.56; CI 1.25–1.95) and possibly
cortical (OR 1.25; CI 0.96–1.63) cataracts, but not to posterior
subcapsular cataract or cataract surgery. After further adjustment for
diabetes, smoking, and education, the association between myopia and
incident cataract surgery was attenuated (OR 1.60; CI 0.96–2.64), but
the associations between hyperopia and incident nuclear and cortical
cataracts were unchanged.
conclusions. These data support the cross-sectional association between myopia and
nuclear cataract seen in other population-based studies, but provide no
evidence of a relationship between myopia and 5-year incident cataract.
Hyperopia may be related weakly to incident nuclear and cortical
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