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Jugnoo S. Rahi, Carol Dezateaux; Measuring and Interpreting the Incidence of Congenital Ocular Anomalies: Lessons from a National Study of Congenital Cataract in the UK. Invest. Ophthalmol. Vis. Sci. 2001;42(7):1444-1448.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. Prevention of visual impairment due to congenital cataract is an
international priority. Estimates of incidence are required for
implementation and assessment of preventive strategies, but are not
widely available, despite routine monitoring of birth defects at a
national level in many industrialized countries. The purpose of this
study was to determine the incidence of new diagnosis of congenital and
infantile cataract in the United Kingdom.
methods. All children with newly diagnosed congenital and infantile cataract in
the United Kingdom in 1 year from October 1995 through September 1996
were identified using independent ophthalmic and pediatric national
active surveillance schemes. Capture–recapture analysis was used to
estimate completeness of ascertainment. Annual age-specific and
cumulative incidence were estimated and adjusted for ascertainment.
results. Two hundred forty-eight children with newly diagnosed congenital or
infantile cataract were identified—an estimated 92% of eligible
cases. The adjusted annual age-specific incidence of new diagnosis of
congenital and infantile cataract was highest in the first year of
life, being 2.49 per 10,000 children (95% confidence interval [CI],
2.10–2.87). Adjusted cumulative incidence at 5 years was 3.18
per 10,000 (95% CI, 2.76–3.59), increasing to 3.46 per 10,000 by 15
years (95% CI, 3.02–3.90). Incidence of bilateral cataract was higher
than that of unilateral, but incidence did not vary by sex or country
conclusions. These estimates of congenital and infantile cataract incidence were
higher than reported previously from routine sources relying on passive
notification around the time of birth. Studies of congenital ocular
anomalies that are not always readily diagnosed at birth should
consider the potential influence on disease frequency of diagnostic
practices as well as of underlying disease
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