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Ruth E. Manny, Mohamed Hussein, Mitchell Scheiman, Daniel Kurtz, Kathy Niemann, Kathleen Zinzer, the COMET Study Group; Tropicamide (1%): An Effective Cycloplegic Agent for Myopic Children. Invest. Ophthalmol. Vis. Sci. 2001;42(8):1728-1735.
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purpose. To evaluate the cycloplegic effect of 1% tropicamide in myopic
children and to determine whether its efficacy is associated with age,
gender, iris color, ethnicity, magnitude of the refractive error, or
methods. Four hundred sixty-nine children enrolled in the Correction of Myopia
Evaluation Trial (COMET; a multicenter, randomized, double-masked
clinical trial evaluating the rate of progression of juvenile-onset
myopia in children wearing progressive-addition versus single-vision
lenses) were given 1 drop of proparacaine in each eye followed 1 minute
later by 1 drop of 1% tropicamide and then a second drop of 1%
tropicamide 4 to 6 minutes later. Five accommodative responses to
20/100 letters located at 4 m and 33 cm were obtained in each eye
with an autorefractor, 20 minutes after the second drop. Residual
accommodation was calculated as the difference between the mean
spherical equivalent responses obtained at the two distances. An
examiner graded iris color, and ethnicity was reported by the
children’s parents or guardians.
results. The mean residual accommodation was small: 0.38 ± 0.41 diopters
(D) in the right eye and 0.30 ± 0.41 D in the left eye. Small but
statistically significant differences in residual accommodation were
associated with ethnicity, but not with any of the other factors.
conclusions. Tropicamide (1%) is an effective cycloplegic agent in myopic
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