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Caroline C. W. Klaver, Jacqueline J. M. Assink, Redmer van Leeuwen, Roger C. W. Wolfs, Johannes R. Vingerling, Theo Stijnen, Albert Hofman, Paulus T. V. M. de Jong; Incidence and Progression Rates of Age-Related Maculopathy: The Rotterdam Study. Invest. Ophthalmol. Vis. Sci. 2001;42(10):2237-2241. doi: https://doi.org/.
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purpose. To describe the incidence rate of age-related macular degeneration
(AMD) and the progression rates of early stages of age-related
maculopathy (ARM), and to study the hierarchy of fundus features that
methods. A group of 4953 subjects aged 55 years and older living in Rotterdam,
The Netherlands, was studied at baseline and at 2-year follow-up to
determine the incidence of neovascular and atrophic AMD. A subgroup of
1244 subjects was studied for progression of early stages of ARM.
Fundus transparencies were graded for features of ARM using the
International Classification System. ARM was stratified in four
exclusive stages, according to type of drusen and presence of
results. The overall 2-year cumulative incidence of AMD was 0.2%, increasing to
1.8% in subjects of 85 years and older. Of those in the early stages,
one fourth showed progression to a more severe stage. The most
important predictors for progression were more than 10% of macular
area covered by drusen (odds ratio [OR] 5.7, 95% confidence interval[
CI] 2.9–11.3), presence of depigmentation (OR 4.0, 95% CI
2.5–6.4), and hyperpigmentation (OR 3.4, 95% CI 2.1–5.4).
conclusions. The incidence of AMD appears to be lower in The Netherlands than in the
United States. Progression of early ARM stages occurs in a distinct
pattern at a stable rate, with a large area of drusen and presence of
pigmentary changes as the most important
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