Purchase this article with an account.
Ursula Schmidt-Erfurth, Sven Teschner, Joachim Noack, Reginald Birngruber; Three-Dimensional Topographic Angiography in Chorioretinal Vascular Disease. Invest. Ophthalmol. Vis. Sci. 2001;42(10):2386-2394.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
purpose. To evaluate a new angiographic technique that offers three-dimensional
imaging of chorioretinal vascular diseases.
methods. Fluorescein (FA) and indocyanine green angiography (ICGA) were
performed using a confocal scanning laser ophthalmoscope. Tomographic
series with 32 images per set were taken over a depth of 4 mm at an
image frequency of 20 Hz. An axial analysis was performed for each x/y position to determine the
fluorescence distribution along the z-axis. The location
of the onset of fluorescence at a defined threshold intensity was
identified and a depth profile was generated. The overall results of
fluorescence topography were displayed in a gray scale–coded image and
results. Topographic angiography delineated the choriocapillary surface covering
the posterior pole with exposed larger retinal vessels. Superficial
masking of fluorescence by hemorrhage or absorbing fluid did not
preclude detection of underlying diseases. Choroidal neovascularization
(CNV) appeared as a vascular formation with distinct configuration and
prominence. Chorioretinal infiltrates exhibited perfusion defects with
dye pooling. Retinal pigment epithelium detachments (PEDs) demonstrated
dynamic filling mechanisms. Intraretinal extravasation in retinal
vascular disease was detected within a well-demarcated area with
prominent retinal thickening.
conclusions. Confocal topographic angiography allows high-resolution
three-dimensional imaging of chorioretinal vascular and exudative
diseases. Structural vascular changes (e.g., proliferation) are
detected in respect to location and size. Dynamic processes (e.g.,
perfusion defects, extravasation, and barrier dysfunction) are clearly
identified and may be quantified. Topographic angiography is a
promising technique in the diagnosis, therapeutic evaluation, and
pathophysiological evaluation of macular
This PDF is available to Subscribers Only