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Andrew Turpin, Allison M. McKendrick, Chris A. Johnson, Algis J. Vingrys; Performance of Efficient Test Procedures for Frequency-Doubling Technology Perimetry in Normal and Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2002;43(3):709-715.
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purpose. To validate the clinical performance of two new efficient
threshold-estimation procedures for frequency-doubling technology (FDT)
perimetry in both visually normal individuals and patients with
glaucomatous visual field loss.
methods. Forty-one normal subjects (mean age, 48.3 ± 11.6 years) and 50
patients with glaucomatous visual field loss (mean age, 72.7 ±
10.0 years) were tested. Some of these participants were retested
within a 3-month period. FDT perimetry was performed on a color monitor
driven by a visual-stimulus–generating video board, with stimulus
parameters designed to closely mimic those of the commercial FDT
test. Visual field sensitivity was measured using three
procedures: a modified binary search (MOBS) identical with the one used
in the commercial FDT device, a rapid efficient binary search (REBS),
and a procedure the uses Bayesian methods (zippy estimation of
sequential testing; ZEST). The selection of optimum parameters for REBS
and ZEST were based on results from previous simulations.
results. Both ZEST and REBS were 40% to 50% faster than MOBS. All three
methods produced similar visual field sensitivity measures, with 95%
of the differences occurring between ±2 dB for normal subjects and ±3
dB for glaucoma patients. Test–retest performance was similar for all
conclusions. The test time for full-threshold FDT perimetry can be approximately
halved, by using either the ZEST or REBS procedure, without affecting
the accuracy or reliability of the measurements. These findings in
normal subjects and patients with glaucoma provide clinical
confirmation of our previous investigations of these test strategies
that use computer simulation.
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