Purchase this article with an account.
Gary L. Trick, Paul Edwards, Uday Desai, Bruce A. Berkowitz; Early Supernormal Retinal Oxygenation Response in Patients with Diabetes. Invest. Ophthalmol. Vis. Sci. 2006;47(4):1612-1619. doi: 10.1167/iovs.05-0833.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
purpose. To determine whether the human retinal oxygenation response (ΔPO2) to a hyperoxic provocation is abnormal in patients with type I diabetes.
methods. Magnetic resonance imaging (MRI) was used to measure ΔPO2 during 100% oxygen breathing in patients with type I diabetes who had either no clinically detectable retinopathy (n = 5) or mild to moderate background diabetic retinopathy (BDR; n = 5) and in age-matched healthy control subjects (n = 7).
results. Both the patients with diabetes and the control subjects exhibited a significant (P < 0.05) increase in the preretinal vitreous signal intensity on changing from room air breathing to oxygen inhalation (i.e., 5 minutes). However, only diabetic patients demonstrated significant (P < 0.05) increases in ΔPO2 between measurements made at 5 minutes of oxygen inhalation and measurements at longer durations of hyperoxia (15, 25, and 35 minutes). Furthermore, ΔPO2 was significantly (P < 0.05) greater in patients with diabetes than in control subjects, but there was no significant difference in ΔPO2 (P > 0.05) between patients with diabetes, with or without retinopathy. Age and ΔPO2 correlated significantly (P < 0.05) in control subjects but not in patients with diabetes. In control subjects, ΔPO2 was relatively uniform panretinally, whereas in the diabetic group, changes in oxygenation response were spatially inhomogeneous.
conclusions. These results demonstrate, for the first time, that MRI ΔPO2 detects a significant supernormal retinal oxygenation response in patients with type I diabetes, even before the appearance of retinopathy. This study raises the possibility of using MRI measurements of ΔPO2 to monitor therapeutic efficacy in human trials.
This PDF is available to Subscribers Only