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Lucia Galli-Resta, Marco Piccardi, Lucia Ziccardi, Antonello Fadda, Angelo Minnella, Dario Marangoni, Giorgio Placidi, Giovanni Resta, Benedetto Falsini; Early Detection of Central Visual Function Decline in Cone–Rod Dystrophy by the Use of Macular Focal Cone Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2013;54(10):6560-6569. doi: https://doi.org/10.1167/iovs.13-12676.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone–rod dystrophy (CRD).
A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field.
Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and—in 50% of the cases—fERG loss anticipated acuity loss of several years.
Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
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