April 1974
Volume 13, Issue 4
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Articles  |   April 1974
Experimental Ocular Irradiation with Accelerated Protons
Author Affiliations
  • IAN J. CONSTABLE
    Department of Retina Research, Retina Foundation, Boston, and the Department of Physics, Harvard University, Cambridge, Mass.
  • ANDREAS M. KOEHLER
    Department of Retina Research, Retina Foundation, Boston, and the Department of Physics, Harvard University, Cambridge, Mass.
Investigative Ophthalmology & Visual Science April 1974, Vol.13, 280-287. doi:
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      IAN J. CONSTABLE, ANDREAS M. KOEHLER; Experimental Ocular Irradiation with Accelerated Protons. Invest. Ophthalmol. Vis. Sci. 1974;13(4):280-287.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

High-energy proton beams of 7 mm. diameter or less were used to irradiate monkey eyes. When the Bragg peak was positioned immediately in front of the retina, it was possible to apply an acute radiation burn to a discrete area of the retina and choroid while delivering much smaller doses to other ocular and orbital tissues. The minimal scatter, finite penetration, and advantageous dose-distribution curve for soft tissues make this mode of radiotherapy very attractive for the treatment of ocular and orbital tumors.

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