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Abstract
The penetration of labeled prednisolone phosphate into the aqueous humor and cornea of rabbits was measured at times up to six hours after the addition of one drop to the cornea in various vehicles. Adsorbobase produced a marked increase in both corneal and aqueous humor content over sodium chloride solution. Benzalkonium chloride (0.01 per cent) increased the penetration of prednisolone in Adsorbobase but not in sodium chloride solution. The use of benzalkonium chloride as a preservative in vehicles which increase corneal retention time appears to be contraindicated in steroid preparations.