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Abstract
We produced an experimental animal model simulating intravitreal neovascularization by injecting 0.1 ml. of a solution containing 15 mg. of ammonium chloride (NH4Cl) into the vitreous cavity of albino rabbits. This dosage causes exudative retinal detachment, destruction of the retina, liquefaction of the vitreous, contraction of the posterior hyaloid membrane, and only minimal retinal vessel damage. Contraction of the posterior hyaloid membrane draws the retinal vessels into the mid-vitreous cavity. The intravitreally displaced retinal vessels provide an excellent model for evaluation of treatment modalities for intravitreal neovascularization.