May 1974
Volume 13, Issue 5
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Articles  |   May 1974
A Pharmacodynamic Study of the Inhibitory Effects of L-Norepinephrine, L-Epinephrine, and D, L-Isoproterenol on Aqueous Humor Formation in the Enucleated, Arterially Perfused Cat Eye
Author Affiliations
  • FRANK J. MACRI
    Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
  • STANLEY J. CEVARIO
    Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
Investigative Ophthalmology & Visual Science May 1974, Vol.13, 392-395. doi:
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      FRANK J. MACRI, STANLEY J. CEVARIO; A Pharmacodynamic Study of the Inhibitory Effects of L-Norepinephrine, L-Epinephrine, and D, L-Isoproterenol on Aqueous Humor Formation in the Enucleated, Arterially Perfused Cat Eye. Invest. Ophthalmol. Vis. Sci. 1974;13(5):392-395.

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Abstract

L-norepinephrine, l-epinephrine, and d, l-isoproterenol have been found to decrease the elevated aqueous humor formation induced by acetylcholine plus eserine (Ach+Es) in the enucleated, arterially perfused cat eye. Utilizing pharmacological criteria, their action was determined to be stimulatory on the E-l sites of sympathetic, ganglion-like receptors. It has been reported that the Ach+Es-induced increase of aqueous humor formation is due to an increase of ultrafiltration probably brought about by constriction of efferent blood vessels from the ciliary processes. It is suggested here that the decrease in inflow brought about by the adrenergic amines is probably the result of vasoconstriction of afferent ciliary process blood vessels with a resultant decrease of ultrafiltration.

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