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YOSHIHITO HONDA, STEVEN M. PODOS, BERNARD BECKER; The Effect of Diphenylhydantoin on the Electroretinogram of Rabbits II. Effects of Hypoxia and Potassium. Invest. Ophthalmol. Vis. Sci. 1973;12(8):573-578.
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Hypoxia decreased the electroretinogram (ERG) amplitude of the in vitro rabbit retina preparation. Diphenylhydantoin sodium (DPH) protected the retinal activity from the inhibition of oxygen deprivation. This effect was more prominent on P II than on P III. The P III component of the ERG, isolated by cooling, was not enhanced by administration of DPH. The DPH-induced enhancement of P II observed in the standard medium (K+ = 3.6 mM.) was suppressed in media of high-potassium concentrations (4.6 to 10.1 mM.) The potassium concentration of the extracellular space proved to be an important factor in the effect of DPH on the retina. The main active site of DPH in the retina appeared to be the origin of P II or the areas related to the generation of P II.
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