August 1971
Volume 10, Issue 8
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Articles  |   August 1971
Conjunctival Ultrastructure in Mucolipidosis III (Pseudo-Hurler Polydystrophy)
Author Affiliations
  • HARRY A. QUIGLEY
    Eye Pathology Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Md., and the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Ill.
  • MORTON F. GOLDBERG
    Eye Pathology Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Md., and the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Ill.
Investigative Ophthalmology & Visual Science August 1971, Vol.10, 568-580. doi:
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    • Get Citation

      HARRY A. QUIGLEY, MORTON F. GOLDBERG; Conjunctival Ultrastructure in Mucolipidosis III (Pseudo-Hurler Polydystrophy). Invest. Ophthalmol. Vis. Sci. 1971;10(8):568-580.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Conjunctival biopsies from two sibs with mucolipidosis III and from their clinically normal parents were examined by histochemistry and electron microscopy. Connective tissue cells were filled with single membrane-limited vacuoles which frequently contained membranous lamellar material. These findings indicate abnormal mucopolysaccharide and glycolipid accumulation in this disorder and suggest a mechanism for the corneal clouding in these patients.

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