September 1971
Volume 10, Issue 9
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Articles  |   September 1971
Effects of Some Metabolic Inhibitors on the Electrical Potential Difference and Short-Circuit Current Across the Lens of the Toad Bufo Marinus
Author Affiliations
  • P. J. BENTLEY
    Departments of Ophthalmology and Pharmacology, Mount Sinai School of Medicine of The City University of New York, Fifth Avenue and 100th Street, New York, N. Y. 10029
  • OSCAR A. CANDIA
    Departments of Ophthalmology and Pharmacology, Mount Sinai School of Medicine of The City University of New York, Fifth Avenue and 100th Street, New York, N. Y. 10029
Investigative Ophthalmology & Visual Science September 1971, Vol.10, 672-676. doi:
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      P. J. BENTLEY, OSCAR A. CANDIA; Effects of Some Metabolic Inhibitors on the Electrical Potential Difference and Short-Circuit Current Across the Lens of the Toad Bufo Marinus. Invest. Ophthalmol. Vis. Sci. 1971;10(9):672-676.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The short-circuit current (SCC) across the isolated lens of the toad Bufo marinus can be abolished by iodoacetate or ouabain but is not altered by 2,4-dinitrophenol, acetazolamide, or amiloride. Ethacrynic acid changes the SCC little and not in a manner comparable with that of ouabain. Ouabain and iodoacetate are effective only when placed at the anterior face of the lens from where they also reduce the potential difference (PD).

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