December 1971
Volume 10, Issue 12
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Articles  |   December 1971
Isoproterenol-Induced Changes of Cell Proliferation in Rat Lens Epithelium
Author Affiliations
  • LUDWIG VON SALLMANN
    Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md. 20014
  • PATRICIA GRIMES
    Laboratory of Neurophysiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md. 20014
Investigative Ophthalmology & Visual Science December 1971, Vol.10, 943-947. doi:
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      LUDWIG VON SALLMANN, PATRICIA GRIMES; Isoproterenol-Induced Changes of Cell Proliferation in Rat Lens Epithelium. Invest. Ophthalmol. Vis. Sci. 1971;10(12):943-947.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The epithelium of the avascular, noninnervated lens was used to study the influence of isoproterenol on cell division. Contrary to the well-known and specific stimulation of deoxyribonucleic acid (DNA) synthesis and cell division in the salivary glands of rats and mice by this catecholamine, the rat lens epithelium responded to a single dose of either locally or systemically administered drug with a transitory decrease of DNA synthesis at 16 hours and of mitosis eight hours later. A secondary stimulation of mitotic activity occurred at 48 hours when a high systemic dose of isoproterenol was given, but it could not be evoked by the lower local doses.

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