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Abstract
Experimental hypersensitivity to epinephrine and to some of its analogues was induced in the rabbit. These changes included chemosis, limbal hyperemia, subepithelial corneal infiltrates, and anterior chamber cells and fare; changes already described in human epinephrine hypersensitivity. Positive skin reactions and circulating antibody were recorded after systemic immunization to polyepinephrine; only skin sensitivity occurred in polyaldomet immunization. This experimental model closely simulates epinephrine hypersensitivity as seen in man.