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SAMUEL B. ARONSON, RICHARD SASSETTI; Experimental Ocular Hypersensitivity to Polyepinephrine and its analogues. Invest. Ophthalmol. Vis. Sci. 1970;9(1):12-19.
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Experimental hypersensitivity to epinephrine and to some of its analogues was induced in the rabbit. These changes included chemosis, limbal hyperemia, subepithelial corneal infiltrates, and anterior chamber cells and fare; changes already described in human epinephrine hypersensitivity. Positive skin reactions and circulating antibody were recorded after systemic immunization to polyepinephrine; only skin sensitivity occurred in polyaldomet immunization. This experimental model closely simulates epinephrine hypersensitivity as seen in man.
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