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MONTE G. HOLLAND; Chloride Ion Transport in the Isolated Ciliary Body II. Ion Substitution Experiments. Invest. Ophthalmol. Vis. Sci. 1970;9(1):30-41.
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The membrane potential (E), short circuit current (I8c), and resistance (R) of the experimentally isolated cat ciliary body were studied in several electrolyte media in which chloride or sodium ions were replaced by organic anions or cations. It was concluded that 90 per cent of the membrane current was carried by chloride ions and that the chloride ion active transport system depended on the presence of sodium ions in the electrolyte medium. The effect of pH on the same electrophysiologic parameters of active transport was also investigated. The I8c was maximum at pH 8.5 whereas E was maximum at pH 7.5. Acid pH markedly diminished both short-circuit current and membrane potential.
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