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DANIEL M. ALBERT, ALAN S. RABSON, ALBERT J. DALTON; Tissue Culture Study of Human Retinoblastoma. Invest. Ophthalmol. Vis. Sci. 1970;9(1):64-72.
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Cells derived from four human retinoblastomas were maintained in culture for periods ranging from 2 to 24 months. The tumors grew in vitro in a biphasic manner with an undifferentiated stroma attached to the surface of the tissue culture flask and clusters of well-differentiated retinoblastoma cells growing in suspension. The cells in suspension continued to produce Flexner-Wintersteiner rosettes and on electron microscopy contained microtubules.
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