October 1970
Volume 9, Issue 10
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Articles  |   October 1970
The Decay Kinetics of Substances Which Leave the Anterior Chamber by Bulk Flow
Author Affiliations
  • MICHAEL KOTTLER
    National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md.
  • RICHARD BRUBAKER
    National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md.
  • FRANK MACRI
    National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md.
Investigative Ophthalmology & Visual Science October 1970, Vol.9, 758-764. doi:
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      MICHAEL KOTTLER, RICHARD BRUBAKER, FRANK MACRI; The Decay Kinetics of Substances Which Leave the Anterior Chamber by Bulk Flow. Invest. Ophthalmol. Vis. Sci. 1970;9(10):758-764.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The rate at which a tracer substance, 125I-albumin, leaves the anterior chamber by bulk flow was studied with the use of a simulated anterior chamber in dead and living primate eyes. The effect of mechanical mixing employing a simple needle-stylet device was studied. Single exponential decay was found in living eyes both with and without mechanical mixing. In dead, unstirred eyes, single exponential decay was found where simulated inflow was 2.1 µl per minute, but not where it was 7.2 µl per minute. With stirring, however, single exponential decay was found at both rates. Using a plastic anterior chamber simulator, single exponential decay was found only when mechanical mixing was used. The reasons for these differences and the uses of the mechanical mixing device were discussed.

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