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MICHAEL KOTTLER, RICHARD BRUBAKER, FRANK MACRI; The Decay Kinetics of Substances Which Leave the Anterior Chamber by Bulk Flow. Invest. Ophthalmol. Vis. Sci. 1970;9(10):758-764.
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The rate at which a tracer substance, 125I-albumin, leaves the anterior chamber by bulk flow was studied with the use of a simulated anterior chamber in dead and living primate eyes. The effect of mechanical mixing employing a simple needle-stylet device was studied. Single exponential decay was found in living eyes both with and without mechanical mixing. In dead, unstirred eyes, single exponential decay was found where simulated inflow was 2.1 µl per minute, but not where it was 7.2 µl per minute. With stirring, however, single exponential decay was found at both rates. Using a plastic anterior chamber simulator, single exponential decay was found only when mechanical mixing was used. The reasons for these differences and the uses of the mechanical mixing device were discussed.
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