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MERCEDES WEISSENBACHER, MILES A. GALIN, ENDLIAM CHOWCHUVECH, NORBERT SCHACHTER, SAMUEL BARON; Protection by Polyinosinic-Polycytidylic Acid Complex of Rabbit Eye Tissue Cultures Infected with Herpes Simplex Virus Effect of Neomycin and Virus Challenge Dose. Invest. Ophthalmol. Vis. Sci. 1970;9(11):857-864.
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The induction of the interferon mechanism in rabbit corneal, conjunctival, iris, and kidney tissue cultures with polyinosinic-polycytidylic acid complex protects against infections with herpes simplex virus. The degree of protection is inversely proportional to the viral challenge dose and is significantly enhanced by the addition of neomycin. The potential application of these observations to ocular infections of man is considered.
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