October 1968
Volume 7, Issue 5
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Articles  |   October 1968
Structural Alterations Affecting Transparency in Swollen Human Corneas
Author Affiliations
  • JEROME N. GOLDMAN
    Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation Boston, Mass. Cornea Service, Massachusetts Eye and Ear Infirmary Boston, Mass. Department of Physics, Massachusetts Institute of Technology Cambridge, Mass.
  • GEORGE B. BENEDEK
    Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation Boston, Mass. Cornea Service, Massachusetts Eye and Ear Infirmary Boston, Mass. Department of Physics, Massachusetts Institute of Technology Cambridge, Mass.
  • CLAES H. DOHLMAN
    Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation Boston, Mass. Cornea Service, Massachusetts Eye and Ear Infirmary Boston, Mass. Department of Physics, Massachusetts Institute of Technology Cambridge, Mass.
  • BARBARA KRAVITT
    Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation Boston, Mass. Cornea Service, Massachusetts Eye and Ear Infirmary Boston, Mass. Department of Physics, Massachusetts Institute of Technology Cambridge, Mass.
Investigative Ophthalmology & Visual Science October 1968, Vol.7, 501-519. doi:
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      JEROME N. GOLDMAN, GEORGE B. BENEDEK, CLAES H. DOHLMAN, BARBARA KRAVITT; Structural Alterations Affecting Transparency in Swollen Human Corneas. Invest. Ophthalmol. Vis. Sci. 1968;7(5):501-519.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A simple discussion of the theory of the diffraction and scattering of light is presented. This theory is used to explain corneal transparency in terms of microscopic structure, and leads to the prediction that characteristic morphological changes would be found in swollen, opaque corneas. Specifically, it is to be expected that opaque corneas will show marked fluctuations in the index of refraction over distances comparable to, or larger than, the wavelength of light. Examination of all layers of pathological surgical specimens demonstrated morphological changes which were consistent with predictions of this theory.

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